Article
Dopamine transporter genotype and stimulant side effect factors in youth diagnosed with attention-deficit/hyperactivity disorder.
Journal of child and adolescent psychopharmacology - 1 Jun 2009
Gruber Reut, Joober Ridha, Grizenko Natalie, Leventhal Bennett L, Cook Edwin H, Stein Mark A
Abstract excerpt
The dopamine transporter locus (DAT1) has been studied as a risk factor for attention-deficit/hyperactivity disorder (ADHD) and in pharmacogenetic studies of stimulant response. Several prospective studies have reported an association between the homozygous 9 repeat allele of the DAT1 3' untranslated region (UTR) variable number tandem repeat (VNTR) (DAT1 3') and decreased efficacy of methylphenidate (MPH). We...
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