Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter.

1 Sept 1992

Abstract excerpt

The human neutrophil and monocyte-derived serine protease homologues neutrophil elastase (NE), proteinase 3 (PR3), and azurocidin (AZU) are involved in a variety of immune defense reactions. NE and PR3 assist in the destruction of phagocytosed microorganisms, cleave the important connective-tissue protein elastin, and generate chemotactic activities by forming alpha 1-proteinase inhibitor complexes and elastin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Coagulation and Thrombosis Mechanisms
Share to Cell Adhesion Molecules Research
Share to Protease and Inhibitor Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 1518849
DOI: 10.1073/pnas.89.17.8215

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Three human elastase-like genes coordinately expressed in the myelomonocyte lineage are organized as a single genetic locus on 19pter.PMID 1518849Read ↗

Characterization of Four Murine Homologs of the Human ov-serpin Monocyte Neutrophil Elastase Inhibitor MNEI (SERPINB1)Semantic proximity Read ↗

Human Proteinase-3 Expression Is Regulated by PU.1 in Conjunction with a Cytidine-rich ElementSemantic proximity Read ↗

Mutations in ELA2, encoding neutrophil elastase, define a 21-day biological clock in cyclic haematopoiesis.Semantic proximity Read ↗

Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor.Semantic proximity Read ↗

NSP4 is stored in azurophil granules and released by activated neutrophils as active endoprotease with restricted specificity.Semantic proximity Read ↗

PU.1 regulates the expression of the human neutrophil elastase gene.Semantic proximity Read ↗

Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils.Semantic proximity Read ↗

Elimination of neutrophil elastase and the genes for [corrected] adaptor protein complex 3 subunits [corrected] as the cause of trapped neutrophil syndrome in Border collies.Semantic proximity Read ↗

Alpha-1-antitrypsin is produced by human neutrophil granulocytes and their precursors and liberated during granule exocytosis.Semantic proximity Read ↗

Polydom: a secreted protein with pentraxin, complement control protein, epidermal growth factor and von Willebrand factor A domainsSemantic proximity Read ↗

Rapid evolution of a unique family of primate ribonuclease genes.Semantic proximity Read ↗

Neutrophil elastase is severely down-regulated in severe congenital neutropenia independent of ELA2 or HAX1 mutations but dependent on LEF-1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.