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Article

5,10-Methylenetetrahydrofolate reductase polymorphisms and leukemia risk: a HuGE minireview.

American journal of epidemiology - 1 Apr 2003

Robien Kim, Ulrich Cornelia M

Abstract excerpt

Leukemias commonly arise as a result of DNA translocations, inversions, or deletions in genes regulating blood cell development or homeostasis. Folate deficiency has been associated with uracil misincorporation into DNA and DNA double strand breaks during uracil excision repair, thus increasing the risk of chromosomal aberrations. Methylenetetrahydrofolate reductase (MTHFR) directs 5,10-methylenetetrahydrofolate...

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Source

Identifiers

PMID: 12672676
DOI: 10.1093/aje/kwg024

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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