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Article

The poxviral RING protein p28 is a ubiquitin ligase that targets ubiquitin to viral replication factories.

Journal of virology - 1 Jan 2005

Nerenberg Bianca T Hovey, Taylor John, Bartee Eric, Gouveia Kristine, Barry Michele, Früh Klaus

Abstract excerpt

The poxviral RING protein p28 is a virulence factor whose molecular function is unknown. Many cellular RING-containing proteins act as ubiquitin ligases (RING-E3s) connecting selected substrate proteins to the ubiquitination machinery. Here we demonstrate that vaccinia virus p28 and its homologue in myxoma virus, M143R, can mediate the formation of polyubiquitin conjugates, while RING mutants of both p28 and...

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Identifiers

PMID: 15596852
DOI: 10.1128/JVI.79.1.597-601.2005
PMCID: PMC538746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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