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Article

Vaccinia virus-encoded ribonucleotide reductase subunits are differentially required for replication and pathogenesis.

PLoS pathogens - 8 Jul 2010

Gammon Don B, Gowrishankar Branawan, Duraffour Sophie, Andrei Graciela, Upton Chris, Evans David H

Abstract excerpt

Ribonucleotide reductases (RRs) are evolutionarily-conserved enzymes that catalyze the rate-limiting step during dNTP synthesis in mammals. RR consists of both large (R1) and small (R2) subunits, which are both required for catalysis by the R1(2)R2(2) heterotetrameric complex. Poxviruses also enc...

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Identifiers

PMID: 20628573
DOI: 10.1371/journal.ppat.1000984
PMCID: PMC2900304

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20628573-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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