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Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis

11 Feb 2013

Abstract excerpt

Poxviruses are considered less dependent on host functions than other DNA viruses because of their cytoplasmic site of replication and large genomes, which encode enzymes for DNA and mRNA synthesis. Nevertheless, RNAi screens with two independent human genome-scale libraries have identified more than 500 candidate genes that significantly inhibited and a similar number that enhanced replication and spread of...

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PMID: 23401514
DOI: 10.1073/pnas.1300708110

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