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CYP1A1 and CYP1B1 genotypes, haplotypes, and TCDD-induced gene expression in subjects from Seveso, Italy.

Toxicology - 14 Feb 2005

Landi Maria Teresa, Bergen Andrew W, Baccarelli Andrea, Patterson Donald G, Grassman Jean, Ter-Minassian Monica, Mocarelli Paolo, Caporaso Neil, Masten Scott A, Pesatori Angela C, Pittman Gary S, Bell Douglas A

Abstract excerpt

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is highly toxic in experimental animals, and is known to induce cytochrome P450 (CYP) gene expression. We investigated the effect of CYP1A1 and CYP1B1 variant genotypes and haplotypes on CYP1A1 and CYP1B1 mRNA expression and ethoxyresorufin-O-deethylase (EROD) activity in lymphocytes from 121 subjects from the Seveso population, Italy, accidentally exposed to TCDD in...

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PMID: 15596250
DOI: 10.1016/j.tox.2004.08.021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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