Association between CYP1A1 genotype, mRNA expression and enzymatic activity in humans.

doi:10.1097/00008571-199410000-00002

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Article

Association between CYP1A1 genotype, mRNA expression and enzymatic activity in humans.

Pharmacogenetics - 1 Oct 1994

Landi M T, Bertazzi P A, Shields P G, Clark G, Lucier G W, Garte S J, Cosma G, Caporaso N E

Abstract excerpt

Genetic susceptibility factors may play a role in determining adverse effects of exposure to environmental toxins. As a preliminary step to a molecular epidemiological study in a population exposed to 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD), we investigated 20 healthy Caucasian volunteers with a set of putative susceptibility markers including a CYP1A1 Msp I restriction fragment length genetic polymorphism...

Topics

Adult
Aryl Hydrocarbon Hydroxylases
Base Sequence
Cytochrome P-450 CYP1A1
Cytochrome P-450 Enzyme System
DNA Primers
Enzyme Induction
Female
Genotype
Humans
Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Molecular Sequence Data

Oxidoreductases

Polychlorinated Dibenzodioxins

Polymorphism, Genetic

RNA, Messenger

Source

Open in PubMed

Identifiers

PMID: 7894496
DOI: 10.1097/00008571-199410000-00002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7894496-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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