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Both HLA-B*57 and Plasma HIV RNA Levels Contribute to the HIV-Specific CD8 + T Cell Response in HIV Controllers

17 Oct 2013

Abstract excerpt

CD8(+) T cell responses are thought to play an important role during HIV infection, particularly in HIV controllers (HIC) in whom viral replication is spontaneously controlled without any treatment. We have demonstrated that CD8(+) T cells from these subjects are able to suppress viral replication in vitro. In parallel, HIV-specific CD8(+) responses were shown to be strong and of high quality, with proliferative...

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PMID: 24131719
DOI: 10.1128/jvi.02098-13

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