Article
Phenotypic polymorphism of CYP2A6 activity in a Chinese population.
European journal of clinical pharmacology - 1 Aug 2002
Xu Ping, Huang Song-Lin, Zhu Rong-Hua, Han Xing-Mei, Zhou Hong-Hao
Abstract excerpt
AIMS: To investigate the distribution characteristics of CYP2A6 activity in a Chinese population and to examine the sex-related differences in CYP2A6 activities. METHODS: One hundred and twenty healthy volunteers, 63 men and 57 women, were included in the study. Cytochrome P450 (CYP) 2A6 activity was measured using the ratio of urinary 7-hydroxycoumarin (7-OHC) excreted in 8 h after a coumarin dose. The...
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