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Article

Evaluation of the influence of sex and CYP2C19 and CYP2D6 polymorphisms in the disposition of citalopram.

European journal of pharmacology - 25 Jan 2010

Fudio Salvador, Borobia Alberto M, Piñana Enrique, Ramírez Elena, Tabarés Beatriz, Guerra Pedro, Carcas Antonio, Frías Jesús

Abstract excerpt

We investigate the impact of sex and genotype on citalopram disposition in 35 healthy volunteers who received an oral dose of 20mg citalopram within a single-dose bioequivalence study. CYP2C19*2 and *3, and CYP2D6*4 mutations were determined by Real-Time PCR. The influence of sex and genotype was analyzed by a linear mixed model for repeated measures, including formulation, period, sequence, sex, CYP2C19 and...

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Identifiers

PMID: 19840783
DOI: 10.1016/j.ejphar.2009.10.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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