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Article

Incidence and distribution of experimental metastases in mutant mice with defective organ microenvironments (genotypes Sl/Sld and W/Wv).

Cancer research - 15 Apr 1992

Arguello F, Furlanetto R W, Baggs R B, Graves B T, Harwell S E, Cohen H J, Frantz C N

Abstract excerpt

Mice carrying mutations at the Sl (steel) and W (dominant white spotting) loci develop abnormalities on 3 migratory embryonic stem cell populations: hematopoietic stem cells, neural crest-derived melanocytes, and primordial germ cells. Transplantation experiments have indicated that the Sl locus affects the microenvironment where stem cells migrate, proliferate, and differentiate, while the W locus affects the...

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PMID: 1559233

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