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Article

Association of the lumican gene functional 3'-UTR polymorphism with high myopia.

Investigative ophthalmology & visual science - 1 Jan 2010

Lin Hui-Ju, Kung Yung-Jen, Lin Ying-Ju, Sheu Jim J C, Chen Bing-Hung, Lan Yu-Ching, Lai Chih-Ho, Hsu Yu-An, Wan Lei, Tsai Fuu Jen

Abstract excerpt

PURPOSE: The lumican gene (LUM) encodes a major extracellular component of the fibrous mammalian sclera. Alteration in the expression levels of extracellular matrix components may influence scleral shape, which in turn could affect visual acuity. Single-nucleotide polymorphisms (SNPs) in the LUM gene were determined in an investigation of whether LUM gene polymorphisms correlate with high myopia. METHODS:...

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Source

Identifiers

PMID: 19643966
DOI: 10.1167/iovs.09-3612

Genes

LUM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of the lumican gene functional 3'-UTR polymorphism with high myopia.PMID 19643966Read ↗

The association between lumican gene polymorphisms and high myopia.Semantic proximity Read ↗

The association of single nucleotide polymorphisms in the 5'-regulatory region of the lumican gene with susceptibility to high myopia in Taiwan.Semantic proximity Read ↗

Absence of an association between lumican promoter variants and high myopia in the Korean population.Semantic proximity Read ↗

Meta-analysis of the association between lumican gene polymorphisms and susceptibility to high Myopia.Semantic proximity Read ↗

Lack of association between LUM rs3759223 polymorphism and high myopia.Semantic proximity Read ↗

Association between a lumican promoter polymorphism and high myopia in the Chinese population: a meta-analysis of case-control studies.Semantic proximity Read ↗

The association of haplotype at the lumican gene with high myopia susceptibility in Taiwanese patients.Semantic proximity Read ↗

Association of Lumican gene polymorphism with high myopia: a meta-analysis.Semantic proximity Read ↗

Novel mutations in the small leucine-rich repeat protein/proteoglycan (SLRP) genes in high myopiaSemantic proximity Read ↗

Evaluation of proteoglycan gene polymorphisms as risk factors in the genetic susceptibility to high myopia.Semantic proximity Read ↗

Ten SNPs of PAX6, Lumican, and MYOC genes are not associated with high myopia in Han Chinese.Semantic proximity Read ↗

Sclera-related gene polymorphisms in high myopia.Semantic proximity Read ↗

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