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Novel mutations in the small leucine-rich repeat protein/proteoglycan (SLRP) genes in high myopia

20 Nov 2006

Abstract excerpt

The importance of the genetic component in high myopia has been well established in population and family studies, but only a few candidate genes have been explored to date. The extracellular matrix small leucine-rich repeat proteins/proteoglycans (SLRPs) regulate collagen fibril diameter and spacing. Given their role in extracellular matrix assembly and expression in the eye, they are likely to regulate its...

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PMID: 17117407
DOI: 10.1002/humu.20444

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