Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Developmental diethylstilbestrol exposure alters genetic pathways of uterine cytodifferentiation.

Molecular endocrinology (Baltimore, Md.) - 1 Mar 2005

Huang Wei-Wei, Yin Yan, Bi Qun, Chiang Tung-Chin, Garner Neysa, Vuoristo Jussi, McLachlan John A, Ma Liang

Abstract excerpt

The formation of a simple columnar epithelium in the uterus is essential for implantation. Perturbation of this developmental process by exogenous estrogen, such as diethylstilbestrol (DES), results in uterine metaplasia that contributes to infertility. The cellular and molecular mechanism underlying this transformation event is not well understood. Here we use a combination of global gene expression analysis and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Infertility
Share to Keratins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Metaplasia

Share to Pregnancy, Animal

Share to Prenatal Exposure Delayed Effects

Share to Ribonucleases

Share to Uterus

Share to Wnt-5a Protein

Source

Identifiers

PMID: 15591538
DOI: 10.1210/me.2004-0155

Genes

DES

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Developmental diethylstilbestrol exposure alters genetic pathways of uterine cytodifferentiation.PMID 15591538Read ↗

Neonatal diethylstilbestrol exposure disrupts uterine epithelial apical-basal polarity and partial EMT stateSemantic proximity Read ↗

Developmental estrogen exposure in mice disrupts uterine epithelial cell differentiation and causes adenocarcinoma via Wnt/β-catenin and PI3K/AKT signalingSemantic proximity Read ↗

Diethylstilbestrol exposure in utero: A paradigm for mechanisms leading to adult diseaseSemantic proximity Read ↗

Developmental exposure to diethylstilbestrol alters uterine gene expression that may be associated with uterine neoplasia later in lifeSemantic proximity Read ↗

Environmental Exposure, DNA Methylation, and Gene RegulationSemantic proximity Read ↗

Epigenetic Modulation of Inflammatory Pathways in Myometrial Stem Cells and Risk of Uterine FibroidsSemantic proximity Read ↗

Endocrine disruption of early uterine differentiation causes adenocarcinoma mediated by Wnt/β-catenin- and PI3K/AKT signalingSemantic proximity Read ↗

Msx Homeobox Genes Act Downstream of BMP2 to Regulate Endometrial Decidualization in Mice and in HumansSemantic proximity Read ↗

Porcupine-dependent Wnt activity within the uterine epithelium is essential for fertility.Semantic proximity Read ↗

Roles of p63 in the diethylstilbestrol-induced cervicovaginal adenosis.Semantic proximity Read ↗

Early Life Adverse Environmental Exposures Increase the Risk of Uterine Fibroid Development: Role of Epigenetic RegulationSemantic proximity Read ↗

Mice lacking uterine enhancer of zeste homolog 2 have transcriptomic changes associated with uterine epithelial proliferation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.