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Article

Roles of p63 in the diethylstilbestrol-induced cervicovaginal adenosis.

Development (Cambridge, England) - 1 Apr 2004

Kurita Takeshi, Mills Alea A, Cunha Gerald R

Abstract excerpt

Women exposed to diethylstilbestrol (DES) in utero develop abnormalities, including cervicovaginal adenosis that can lead to cancer. We report that transient disruption of developmental signals by DES permanently changes expression of p63, thereby altering the developmental fate of Müllerian duct epithelium. The cell fate of Müllerian epithelium to be columnar (uterine) or squamous (cervicovaginal) is determined...

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Source

Identifiers

PMID: 14998922
DOI: 10.1242/dev.01038

Genes

DES

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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