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Article

Distinct roles of Candida albicans drug resistance transcription factors TAC1, MRR1, and UPC2 in virulence.

Eukaryotic cell - 1 Jan 2014

Lohberger Andrea, Coste Alix T, Sanglard Dominique

Abstract excerpt

Azoles are widely used in antifungal therapy in medicine. Resistance to azoles can occur in Candida albicans principally by overexpression of multidrug transporter gene CDR1, CDR2, or MDR1 or by overexpression of ERG11, which encodes the azole target. The expression of these genes is controlled by the transcription factors (TFs) TAC1 (involved in the control of CDR1 and CDR2), MRR1 (involved in the control of...

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Share to ATP Binding Cassette Transporter, Subfamily B
Share to Azoles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Drug Resistance, Fungal

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Share to Gene Expression Regulation, Fungal

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Source

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Identifiers

PMID: 24243794
DOI: 10.1128/EC.00245-13
PMCID: PMC3910953

Genes

TAC1
CDR2

Provenance

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