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Article

The ability of Sgs1 to interact with DNA topoisomerase III is essential for damage-induced recombination.

DNA repair - 3 Feb 2005

Ui Ayako, Seki Masayuki, Ogiwara Hideaki, Onodera Ryoko, Fukushige Shin-ichi, Onoda Fumitoshi, Enomoto Takemi

Abstract excerpt

SGS1 encodes a protein having DNA helicase activity, and a mutant allele of SGS1 was identified as a suppressor of the slow growth phenotype of top3 mutants. In this study, we examined whether Sgs1 prevents formation of DNA double strand breaks (DSBs) or is involved in DSB repair following exposure to methyl methanesulfonate (MMS). An analysis by pulsed-field gel electrophoresis and epistasis analyses indicated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15590327
DOI: 10.1016/j.dnarep.2004.09.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The ability of Sgs1 to interact with DNA topoisomerase III is essential for damage-induced recombination.PMID 15590327Read ↗

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Genetic analysis of the Saccharomyces cerevisiae Sgs1 helicase defines an essential function for the Sgs1-Top3 complex in the absence of SRS2 or TOP1.Semantic proximity Read ↗

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