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Article

Sgs1 helicase activity is required for mitotic but apparently not for meiotic functions.

Molecular and cellular biology - 1 Sept 2000

Miyajima A, Seki M, Onoda F, Shiratori M, Odagiri N, Ohta K, Kikuchi Y, Ohno Y, Enomoto T

Abstract excerpt

The SGS1 gene of Saccharomyces cerevisiae is a homologue for the Bloom's syndrome and Werner's syndrome genes. The disruption of the SGS1 gene resulted in very poor sporulation, and the majority of the cells were arrested at the mononucleated stage. The recombination frequency measured by a return-to-growth assay was reduced considerably in sgs1 disruptants. However, double-strand break formation, which is a key...

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Source

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Identifiers

PMID: 10938117
DOI: 10.1128/MCB.20.17.6399-6409.2000
PMCID: PMC86115

Genes

RAD17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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