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Article

BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis.

The Journal of cell biology - 9 Jun 2014

Broering Tyler J, Alavattam Kris G, Sadreyev Ruslan I, Ichijima Yosuke, Kato Yasuko, Hasegawa Kazuteru, Camerini-Otero R Daniel, Lee Jeannie T, Andreassen Paul R, Namekawa Satoshi H

Abstract excerpt

During meiosis, DNA damage response (DDR) proteins induce transcriptional silencing of unsynapsed chromatin, including the constitutively unsynapsed XY chromosomes in males. DDR proteins are also implicated in double strand break repair during meiotic recombination. Here, we address the function...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24914237
DOI: 10.1083/jcb.201311050
PMCID: PMC4050732

Genes

BRCA1
ATR
TOPBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24914237-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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