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Article

The mammalian mid-pachytene checkpoint: meiotic arrest in spermatocytes with a mutation in Atm alone or in combination with a Trp53 (p53) or Cdkn1a (p21/cip1) mutation.

Cytogenetic and genome research - 1 Jan 2004

Ashley T, Westphal C, Plug-de Maggio A, de Rooij D G

Abstract excerpt

ATM, the protein product of the gene mutated in the human autosomal recessive disorder ataxia telangiectasia, is involved in detection of double strand breaks (DSBs) and is a key component of the damage surveillance network of cell cycle proteins. In somatic cells ATM phosphorylates many other pr...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15467370
DOI: 10.1159/000080603

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15467370-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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The mammalian mid-pachytene checkpoint: meiotic arrest in spermatocytes with a mutation in Atm alone or in combination with a Trp53 (p53) or Cdkn1a (p21/cip1) mutation.PMID 15467370Read ↗

The ATM signaling cascade promotes recombination-dependent pachytene arrest in mouse spermatocytes.Semantic proximity Read ↗

ATM: the product of the gene mutated in ataxia-telangiectasia.Semantic proximity Read ↗

Atm deficiency results in severe meiotic disruption as early as leptonema of prophase ISemantic proximity Read ↗

Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages.Semantic proximity Read ↗

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BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation.Semantic proximity Read ↗

ATM: genome stability, neuronal development, and cancer cross paths.Semantic proximity Read ↗

ATM promotes the obligate XY crossover and both crossover control and chromosome axis integrity on autosomes.Semantic proximity Read ↗

The pachytene checkpoint.Semantic proximity Read ↗

CHFR is important for the survival of male premeiotic germ cells.Semantic proximity Read ↗

Surveillance of different recombination defects in mouse spermatocytes yields distinct responses despite elimination at an identical developmental stage.Semantic proximity Read ↗

Ataxia-telangiectasia and the ATM gene: Linking neurodegeneration, immunodeficiency, and cancer to cell cycle checkpointsSemantic proximity Read ↗

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