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Article

A sialidase mutant displaying trans-sialidase activity.

Journal of molecular biology - 28 Jan 2005

Paris Gastón, Ratier Laura, Amaya María Fernanda, Nguyen Tong, Alzari Pedro M, Frasch Alberto Carlos C

Abstract excerpt

Trypanosoma cruzi, the agent of Chagas disease, expresses a modified sialidase, the trans-sialidase, which transfers sialic acid from host glycoconjugates to beta-galactose present in parasite mucins. Another American trypanosome, Trypanosoma rangeli, expresses a homologous protein that has sialidase activity but is devoid of transglycosidase activity. Based on the recently determined structures of T.rangeli...

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Source

Identifiers

PMID: 15588836
DOI: 10.1016/j.jmb.2004.09.031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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