A single tyrosine differentiates active and inactive Trypanosoma cruzi trans-sialidases.

doi:10.1016/0378-1119(95)00175-6

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Article

A single tyrosine differentiates active and inactive Trypanosoma cruzi trans-sialidases.

Gene - 4 Jul 1995

Cremona M L, Sánchez D O, Frasch A C, Campetella O

Abstract excerpt

Several genes encode members of the Trypanosoma cruzi (Tc) trans-sialidase (TS) family. These proteins contain an enzymatic domain on the N terminus, the only one required for TS activity, and an antigenic domain (SAPA (shed acute phase antigen) amino acid (aa) repeats) on the C terminus. Only so...

Topics

Animals
Base Sequence
Blotting, Western
DNA Primers
Genes, Protozoan
Genetic Variation
Kinetics
Molecular Sequence Data
Neuraminidase
Polymerase Chain Reaction
Repetitive Sequences, Nucleic Acid
Restriction Mapping
Species Specificity
Trypanosoma cruzi
Tyrosine

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