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Article

Rational design of a new Trypanosoma rangeli trans-sialidase for efficient sialylation of glycans.

PloS one - 1 Jan 2014

Jers Carsten, Michalak Malwina, Larsen Dorte M, Kepp Kasper P, Li Haiying, Guo Yao, Kirpekar Finn, Meyer Anne S, Mikkelsen Jørn D

Abstract excerpt

This paper reports rational engineering of Trypanosoma rangeli sialidase to develop an effective enzyme for a potentially important type of reactivity: production of sialylated prebiotic glycans. The Trypanosoma cruzi trans-sialidase and the homologous T. rangeli sialidase has previously been used to investigate the structural requirements for trans-sialidase activity. We observed that the T. cruzi...

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Identifiers

PMID: 24404142
DOI: 10.1371/journal.pone.0083902
PMCID: PMC3880268

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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