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Sialic acid: a sweet swing between mammalian host and Trypanosoma cruzi

1 Jan 2012

Abstract excerpt

Commonly found at the outermost ends of complex carbohydrates in extracellular medium or on outer cell membranes, sialic acids play important roles in a myriad of biological processes. Mammals synthesize sialic acid through a complex pathway, but Trypanosoma cruzi, the agent of Chagas' disease, evolved to obtain sialic acid from its host through a trans-sialidase (TcTS) reaction. Studies of the parasite cell...

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PMID: 23230438
DOI: 10.3389/fimmu.2012.00356

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