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Role of Trypanosoma cruzi Trans-sialidase on the Escape from Host Immune Surveillance

23 Mar 2016

Abstract excerpt

Chagas disease is caused by the flagellate protozoan Trypanosoma cruzi, affecting millions of people throughout Latin America. The parasite dampens host immune response causing modifications in diverse lymphoid compartments, including the thymus. T. cruzi trans-sialidase (TS) seems to play a fundamental role in such immunopathological events. This unusual enzyme catalyses the transference of sialic acid molecules...

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PMID: 27047464
DOI: 10.3389/fmicb.2016.00348

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