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Article

Identification of a second catalytically active trans-sialidase in Trypanosoma brucei.

Biochemical and biophysical research communications - 18 Nov 2011

Nakatani Fumiki, Morita Yasu S, Ashida Hisashi, Nagamune Kisaburo, Maeda Yusuke, Kinoshita Taroh

Abstract excerpt

The procyclic stage of Trypanosoma brucei is covered by glycosylphosphatidylinositol (GPI)-anchored surface proteins called procyclins. The procyclin GPI anchor contains a side chain of N-acetyllactosamine repeats terminated by sialic acids. Sialic acid modification is mediated by trans-sialidases expressed on the parasite's cell surface. Previous studies suggested the presence of more than one active...

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Identifiers

PMID: 22040733
DOI: 10.1016/j.bbrc.2011.10.085

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GPI

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