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Article

Biochemical characterization of trans-sialidase TS1 variants from Trypanosoma congolense.

BMC biochemistry - 30 Jul 2011

Koliwer-Brandl Hendrik, Gbem Thaddeus T, Waespy Mario, Reichert Olga, Mandel Philipp, Drebitz Eric, Dietz Frank, Kelm Sørge

Abstract excerpt

BACKGROUND: Animal African trypanosomiasis, sleeping sickness in humans and Nagana in cattle, is a resurgent disease in Africa caused by Trypanosoma parasites. Trans-sialidases expressed by trypanosomes play an important role in the infection cycle of insects and mammals. Whereas trans-sialidases of other trypanosomes like the American T. cruzi are well investigated, relatively little research has been done on...

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PMID: 21801439
DOI: 10.1186/1471-2091-12-39
PMCID: PMC3173295

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