Article
Altered replicative capacity of recombinant HIV type 1 containing mutations at codons 26 and 29 of the viral protease.
AIDS research and human retroviruses - 1 Nov 2004
Melón Santiago, Gil-Roda Cristina, de Oña María, Erice Alejo
Abstract excerpt
HIV-1 protease activity is essential for viral replication. In spite of the high rates of HIV mutation, the active site of protease (residues 24-29) is a conserved site, where mutations have not been previously described. To determine the effect of mutations at positions T26 and A29 of the viral protease and its viability in recombinant HIV-1 strains, Sup-t1 cells were transfected by electroporation with PCR...
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