Article
Functional correlation between a novel amino acid insertion at codon 19 in the protease of human immunodeficiency virus type 1 and polymorphism in the p1/p6 Gag cleavage site in drug resistance and replication fitness.
Journal of virology - 1 Jun 2006
Brann Terrence W, Dewar Robin L, Jiang Min-Kan, Shah Akram, Nagashima Kunio, Metcalf Julia A, Falloon Judith, Lane H Clifford, Imamichi Tomozumi
Abstract excerpt
Population-based sequence analysis revealed the presence of a variant of human immunodeficiency virus type 1 (HIV-1) containing an insertion of amino acid Ile in the protease gene at codon 19 (19I) and amino acid substitutions in the protease at codons 21 (E21D) and 22 (A22V) along with multiple mutations associated with drug resistance, M46I/P63L/A71V/I84V/I93L, in a patient who had failed protease inhibitor...
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