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Article

Homocysteine concentrations in adults with trisomy 21: effect of B vitamins and genetic polymorphisms.

The American journal of clinical nutrition - 1 Dec 2004

Fillon-Emery Nathalie, Chango Abalo, Mircher Clotilde, Barbé Françoise, Bléhaut Henri, Herbeth Bernard, Rosenblatt David S, Réthoré Marie-Odile, Lambert Daniel, Nicolas Jean Pierre

Abstract excerpt

BACKGROUND: The effects of supplementation with B vitamins and of common polymorphisms in genes involved in homocysteine metabolism on plasma total homocysteine (tHcy) concentrations in trisomy 21 are unknown. OBJECTIVES: We aimed to determine the effects of orally administered folic acid and of folic acid combined with vitamin B-12, vitamin B-6, or both on tHcy in adults with trisomy 21. The study was also...

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Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15585767
DOI: 10.1093/ajcn/80.6.1551

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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