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Article

Role of folic acid depletion on homocysteine serum level in children and adolescents with epilepsy and different MTHFR C677T genotypes.

Seizure - 1 Jun 2012

Coppola Giangennaro, Ingrosso Diego, Operto Francesca Felicia, Signoriello Giuseppe, Lattanzio Francamaria, Barone Eugenia, Matera Sabino, Verrotti Alberto

Abstract excerpt

Homocysteine (Hcy) is a sulfur-containing amino acid involved in methionine metabolism. An elevated total plasma Hcy concentration (tHcy) is a risk factor for vascular disease. The present study aimed to assess the role of antiepileptic drugs (AEDs) and C677T methylenetetrahydrofolate (MTHFR) polymorphisms on tHcy in pediatric patients with epilepsy treated for at least 6 months with various treatment regimens...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Folic Acid Deficiency

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Share to Methylenetetrahydrofolate Reductase (NADPH2)

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Source

Identifiers

PMID: 22425007
DOI: 10.1016/j.seizure.2012.02.011

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Role of folic acid depletion on homocysteine serum level in children and adolescents with epilepsy and different MTHFR C677T genotypes.PMID 22425007Read ↗

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