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Methylenetetrahydrofolate reductase gene polymorphisms and their association with trisomy 21

1 Jan 2005

Abstract excerpt

OBJECTIVES: To verify whether the frequencies of 5,10-methylenotetrahydrofolate reductase (MTHFR) polymorphisms at positions 677 and 1298 are higher in women with children affected by trisomy 21 than in those with chromosomally normal offspring. METHODS: A case-control study was carried out with 70 women whose children had trisomy 21 and 88 controls whose children were chromosomally normal. The frequencies of...

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PMID: 16353284
DOI: 10.1002/pd.1296

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