Article
Modulation of the homocysteine-betaine relationship by methylenetetrahydrofolate reductase 677 C->t genotypes and B-vitamin status in a large-scale epidemiological study.
The Journal of clinical endocrinology and metabolism - 1 Apr 2007
Holm Pål I, Hustad Steinar, Ueland Per Magne, Vollset Stein Emil, Grotmol Tom, Schneede Jørn
Abstract excerpt
CONTEXT: Betaine is formed from the essential nutrient choline or is supplied from the diet. It serves as a substrate in the betaine-homocysteine methyltransferase reaction and thereby provides methyl groups for the homocysteine-methionine cycle, which is regulated by enzymes dependent on folate, vitamin B12, riboflavin (vitamin B2), or vitamin B6. OBJECTIVE: We investigated how betaine affected total...
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