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Article

Polymorphisms in thymidylate synthase and methylenetetrahydrofolate reductase genes and the susceptibility to esophageal and stomach cancer with smoking.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2000

Gao Chang-Ming, Takezaki Toshiro, Wu Jian-Zhong, Liu Yan-Ting, Ding Jian-Hua, Li Su-Ping, Su Ping, Hu Xu, Kai Hai-Tao, Li Zong-You, Matsuo Keitaro, Hamajima Nobuyuki, Sugimura Haruhiko, Tajima Kazuo

Abstract excerpt

Thymidylate synthetase (TS) and methylenetetrahydrofolate reductase (MTHFR) are major enzymes in the metabolism of folates, involved in DNA 'breaks', instability and hypomethylation. To investigate the possible relations between the TS 3'-UTR and MTHFR C677T polymorphisms and environmental factors impacting on risk of esophageal and stomach cancers, we conducted a case-control study in a high incidence region of...

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PMID: 15244514

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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