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Article

Genetic alterations and protein expression of KIT and PDGFRA in serous ovarian carcinoma.

British journal of cancer - 13 Dec 2004

Lassus H, Sihto H, Leminen A, Nordling S, Joensuu H, Nupponen N N, Butzow R

Abstract excerpt

KIT and PDGFRA are receptor tyrosine kinases that can be specifically inactivated by small-molecule tyrosine kinase inhibitors, notably imatinib mesylate. In ovarian carcinoma, expression of KIT and PDGFRA protein has been documented, but the frequency and the molecular background of expression are poorly known. We analysed the expression of KIT and PDGFRA by immunohistochemistry in 522 serous ovarian carcinomas,...

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Topics

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Share to Chromatography, High Pressure Liquid
Share to Cystadenocarcinoma, Serous

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to In Situ Hybridization, Fluorescence

Share to Neoplasm Staging

Share to Ovarian Neoplasms

Share to Protein Array Analysis

Share to Proto-Oncogene Proteins c-kit

Share to Receptor, Platelet-Derived Growth Factor alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 15583695
DOI: 10.1038/sj.bjc.6602252
PMCID: PMC2409787

Genes

KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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