Article
High KIT and PDGFRA are associated with shorter patients survival in gastroenteropancreatic neuroendocrine tumors, but mutations are a rare event.
Journal of cancer research and clinical oncology - 1 Mar 2012
Knösel Thomas, Chen Yuan, Altendorf-Hofmann Annelore, Danielczok Christine, Freesmeyer Martin, Settmacher Utz, Wurst Christine, Schulz Stefan, Yang Lin Lin, Petersen Iver
Abstract excerpt
PURPOSE: (1) To test whether in genomewide expression profiling differentially expressed genes were also distinct on the protein level including KIT and PDGFRA (2) to correlate the expression with clinicopathological parameters (3) to identify activating mutations that might be eligible for tyrosine kinase inhibitor therapy by mutational analysis of tumors with high expression. METHODS: Gastroenteropancreatic...
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