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Article

Thrombomodulin increases the rate of thrombin inhibition by BPTI.

Biochemistry - 13 Jan 1998

Rezaie A R, He X, Esmon C T

Abstract excerpt

Thrombin undergoes allosteric modulation by thrombomodulin (TM) that results in a shift in macromolecular specificity, blocking fibrinogen clotting while enhancing protein C activation. The TM enhancement of protein C activation involves both an 8-fold decrease in Km and a 200-fold increase in kcat. Although TM-mediated conformational changes in thrombin have been detected by many techniques, the nature of these...

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Identifiers

PMID: 9425093
DOI: 10.1021/bi971271y

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Thrombomodulin increases the rate of thrombin inhibition by BPTI.PMID 9425093Read ↗

The thrombin E192Q-BPTI complex reveals gross structural rearrangements: implications for the interaction with antithrombin and thrombomodulin.Semantic proximity Read ↗

Thrombomodulin changes the molecular surface of interaction and the rate of complex formation between thrombin and protein C.Semantic proximity Read ↗

Lys 42/43/44 and Arg 12 of thrombin-activable fibrinolysis inhibitor comprise a thrombomodulin exosite essential for its antifibrinolytic potential.Semantic proximity Read ↗

Identification of a thrombomodulin interaction site on thrombin-activatable fibrinolysis inhibitor that mediates accelerated activation by thrombin.Semantic proximity Read ↗

Mutations in autolytic loop-2 and at Asp554 of human prothrombin that enhance protein C activation by meizothrombin.Semantic proximity Read ↗

Activation of protein C by the thrombin-thrombomodulin complex: cooperative roles of Arg-35 of thrombin and Arg-67 of protein C.Semantic proximity Read ↗

Amino acid residues in the P6-P'3 region of thrombin-activable fibrinolysis inhibitor (TAFI) do not determine the thrombomodulin dependence of TAFI activation.Semantic proximity Read ↗

The short loop between epidermal growth factor-like domains 4 and 5 is critical for human thrombomodulin function.Semantic proximity Read ↗

The thrombin high-affinity binding site on platelets is a negative regulator of thrombin-induced platelet activation. Structure-function studies using two mutant thrombins, Quick I and Quick II.Semantic proximity Read ↗

Thr90Ser Mutation in Antithrombin is Associated with Recurrent Thrombosis in a Heterozygous Carrier.Semantic proximity Read ↗

Inactivation of active thrombin-activable fibrinolysis inhibitor takes place by a process that involves conformational instability rather than proteolytic cleavage.Semantic proximity Read ↗

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