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Article

Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells.

Journal of lipid research - 1 Feb 2006

Pipalia Nina H, Huang Amy, Ralph Harold, Rujoi Madalina, Maxfield Frederick R

Abstract excerpt

Niemann-Pick disease type C (NPC) is an autosomal recessive genetic disorder manifested by abnormal accumulation of unesterified cholesterol and other lipids. We screened combinatorially synthesized chemical libraries to identify compounds that would partially revert cholesterol accumulation. Cultured CHO cells with NPC phenotypes (CT60 and CT43) were used for screening along with normal CHO cells as a control....

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Source

Identifiers

PMID: 16288097
DOI: 10.1194/jlr.M500388-JLR200

Genes

NPC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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