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Article

A critical evaluation of the ubiquitin-proteasome system in Parkinson's disease.

Biochimica et biophysica acta - 1 Jul 2009

Cook Casey, Petrucelli Leonard

Abstract excerpt

The evidence for impairment in the ubiquitin proteasome system (UPS) in Parkinson's disease (PD) is mounting and becoming increasingly more convincing. However, it is presently unclear whether UPS dysfunction is a cause or result of PD pathology, a crucial distinction which impedes both the understanding of disease pathogenesis and the development of effectual therapeutic approaches. Recent findings discussed...

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Identifiers

PMID: 19419700
DOI: 10.1016/j.bbadis.2009.01.012
PMCID: PMC2828612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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