Article
Expression and mutation analyses of Fas, FLIP and Bcl-2 in granulosa cell tumor of ovary.
Tumori - 1 Jan 2000
Yoo Nam Jin, Kim Min Sung, Lee Sug Hyung
Abstract excerpt
AIMS AND BACKGROUND: Mounting evidence indicates that evasion of apoptosis contributes to tumor pathogenesis. Although both Fas and Bcl-2 are crucial in apoptosis of normal ovarian cells, their roles in ovarian tumors, especially stromal tumors, are largely unknown. The aim of this study was to explore mutation of the Fas gene and expression of the apoptosis-related proteins Fas, FLICE-like inhibitory protein...
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