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Article

Role of RAS signaling in ovarian cancer

4 Nov 2022

Abstract excerpt

The RAS family of proteins is among the most frequently mutated genes in human malignancies. In ovarian cancer (OC), the most lethal gynecological malignancy, RAS , especially KRAS mutational status at codons 12, 13, and 61, ranges from 6–65% spanning different histo-types. Normally RAS regulates several signaling pathways involved in a myriad of cellular signaling cascades mediating numerous cellular processes...

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PMID: 36451660
DOI: 10.12688/f1000research.126337.1

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