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Article

Volatile anesthetic modulation of oligomerization equilibria in a hexameric model peptide.

FEBS letters - 3 Dec 2004

Ghirlanda Giovanna, Hilcove Simon A, Pidikiti Ravindernath, Johansson Jonas S, Lear James D, Degrado William F, Eckenhoff Roderic G

Abstract excerpt

To determine if occupancy of interfacial pockets in oligomeric proteins by volatile anesthetic molecules can allosterically regulate oligomerization equilibria, variants of a three-helix bundle peptide able to form higher oligomers were studied with analytical ultracentrifugation, hydrogen exchange and modeling. Halothane shifted the oligomerization equilibria towards the oligomer only in a mutation predicted to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15581631
DOI: 10.1016/j.febslet.2004.10.087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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