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Article

Maximum-likelihood estimation of demographic parameters using the frequency spectrum of unlinked single-nucleotide polymorphisms.

Genetics - 1 Nov 2004

Adams Alison M, Hudson Richard R

Abstract excerpt

A maximum-likelihood method for demographic inference is applied to data sets consisting of the frequency spectrum of unlinked single-nucleotide polymorphisms (SNPs). We use simulation analyses to explore the effect of sample size and number of polymorphic sites on both the power to reject the null hypothesis of constant population size and the properties of two- and three-dimensional maximum-likelihood...

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Identifiers

PMID: 15579718
DOI: 10.1534/genetics.104.030171
PMCID: PMC1448761

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