Article
Inferring the joint demographic history of multiple populations from multidimensional SNP frequency data.
PLoS genetics - 1 Oct 2009
Gutenkunst Ryan N, Hernandez Ryan D, Williamson Scott H, Bustamante Carlos D
Abstract excerpt
Demographic models built from genetic data play important roles in illuminating prehistorical events and serving as null models in genome scans for selection. We introduce an inference method based on the joint frequency spectrum of genetic variants within and between populations. For candidate models we numerically compute the expected spectrum using a diffusion approximation to the one-locus, two-allele...
Topics
- Africa
- Asia
- Demography
- Europe
- Evolution, Molecular
- Gene Frequency
- History, Ancient
- Humans
- Models, Genetic
- Polymorphism, Single Nucleotide
- Racial Groups