Article
Sampling strategies for frequency spectrum-based population genomic inference.
BMC evolutionary biology - 4 Dec 2014
Robinson John D, Coffman Alec J, Hickerson Michael J, Gutenkunst Ryan N
Abstract excerpt
BACKGROUND: The allele frequency spectrum (AFS) consists of counts of the number of single nucleotide polymorphism (SNP) loci with derived variants present at each given frequency in a sample. Multiple approaches have recently been developed for parameter estimation and calculation of model likelihoods based on the joint AFS from two or more populations. We conducted a simulation study of one of these approaches,...
Topics
- Animals
- Gene Frequency
- Genetics, Population
- Genomics
- Humans
- Models, Genetic
- Polymorphism, Single Nucleotide
- Population Density
- Reference Standards