Article
The allele frequency spectrum in genome-wide human variation data reveals signals of differential demographic history in three large world populations.
Genetics - 1 Jan 2004
Marth Gabor T, Czabarka Eva, Murvai Janos, Sherry Stephen T
Abstract excerpt
We have studied a genome-wide set of single-nucleotide polymorphism (SNP) allele frequency measures for African-American, East Asian, and European-American samples. For this analysis we derived a simple, closed mathematical formulation for the spectrum of expected allele frequencies when the sampled populations have experienced nonstationary demographic histories. The direct calculation generates the spectrum...
Topics
- Black or African American
- Alleles
- Americas
- Asia
- Biometry
- Europe
- Gene Frequency
- Genetic Variation
- Genetics, Population
- Genome, Human
- Humans
- Linkage Disequilibrium
- Models, Genetic
- Polymorphism, Single Nucleotide
- Population Density