Article
Case-control single-marker and haplotypic association analysis of pedigree data.
Genetic epidemiology - 1 Feb 2005
Browning Sharon R, Briley J David, Briley Linda P, Chandra Gyan, Charnecki Jonathan H, Ehm Margaret G, Johansson Kelley A, Jones Brendan J, Karter Andrew J, Yarnall David P, Wagner Michael J
Abstract excerpt
Related individuals collected for use in linkage studies may be used in case-control linkage disequilibrium analysis, provided one takes into account correlations between individuals due to identity-by-descent (IBD) sharing. We account for these correlations by calculating a weight for each individual. The weights are used in constructing a composite likelihood, which is maximized iteratively to form likelihood...
Topics
- Alleles
- Case-Control Studies
- Chromosome Mapping
- Diabetes Mellitus, Type 2
- Genotype
- Haplotypes
- Humans
- Linkage Disequilibrium
- Models, Genetic
- Pedigree