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Article

Maternal substrate utilization programs the development of the metabolic syndrome in male mice exposed to high fat in utero.

Pediatric research - 1 Oct 2009

Hartil Kirsten, Vuguin Patricia M, Kruse Michael, Schmuel Esther, Fiallo Ariana, Vargas Carlos, Warner Matthew J, Durand Jorge L, Jelicks Linda A, Charron Maureen J

Abstract excerpt

Studies were conducted to determine whether maternal substrate utilization during pregnancy affects fetal growth and predisposes offspring to metabolic disease. Female wild-type (WT) and glucose transporter 4 heterozygous mice (G4+/-, a model of altered peripheral substrate utilization) were fed high-fat diet (HFD, 35.5% fat) or control chow (C, 9.5% fat) for 2 wk before mating, throughout pregnancy and lactation...

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Source

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Identifiers

PMID: 19581843
DOI: 10.1203/PDR.0b013e3181b33375
PMCID: PMC2795789

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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