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Article

Mitochondrial injury: a hot spot for parkinsonism and Parkinson's disease?

Science of aging knowledge environment : SAGE KE - 1 Dec 2004

Giasson Benoit I

Abstract excerpt

The recent identification of genes (parkin, DJ-1, and PINK1) involved in recessive autosomal parkinsonism, and the indications that these proteins may have protective effects on the mitochondria, has led to the reemergence of the notion that mitochondrial dysfunction might play a central role in the etiology of sporadic Parkinson's disease (PD). This idea has previously been supported by biochemical analyses...

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Identifiers

PMID: 15576821
DOI: 10.1126/sageke.2004.48.pe42

Genes

PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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